Boston Red Sox (2006-14) ► Oakland Athletics (2014) ► Chicago Cubs (2015-20) ► Washington Nationals (2021) ► St. Louis Cardinals (2021)
| Years | Logo | G | W | L | Sv | K | IP |
| 2006-2008 |  |
60 | 27 | 8 | 0 | 262 | 354 |
| 2009-2014 |  |
182 | 83 | 55 | 0 | 1,124 | 1,163 |
| 2014-2014 |  |
11 | 6 | 4 | 0 | 71 | 76 |
| 2015-2020 |  |
171 | 77 | 44 | 0 | 940 | 1,000 |
| 2021-2021 |  |
16 | 3 | 5 | 0 | 51 | 75 |
| 2021-2021 |  |
12 | 4 | 1 | 0 | 40 | 66 |
| TOTALS | 452 | 200 | 117 | 0 | 2,488 | 2,734 | |
Jon Lester played for the Boston Red Sox, Oakland Athletics, Chicago Cubs, Washington Nationals, and St. Louis Cardinals during his MLB career.
Jon Lester played for 5 teams during his MLB career.
